Contrave contains a combination of bupropion and naltrexone. Bupropion is an antidepressant medicine that can also decrease appetite. Naltrexone is usually given to block the effects of narcotics or alcohol in people with addiction problems. Naltrexone may also curb hunger and food cravings. Contrave is an anorexiant amd is used to help manage weight in obese or overweight adults with weight-related medical problems. This medicine is used together with diet and exercise. Contrave will not treat any weight-related medical condition, such as high blood pressure, diabetes, or high cholesterol. Contrave is not approved to treat depression or other psychiatric conditions, or to help you quit smoking.